The name of the game for San Francisco, for a few consecutive seasons, has been injuries.
How healthy will it be going into this season? And if healthy, can it overcome the two juggernauts in-division?
Let's check out the 49ers' Over/Under win total odds for the 2026 season.
This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.
San Francisco 49ers
Over 9.5: -146 (bet $10 to win $16.85 total)
Under 9.5: +120 (bet $10 to win $22 total)
What to know: The 49ers remarkably won 12 games in 2025 despite dealing with a plethora of injuries to several key players. Brock Purdy missed eight games, while Fred Warner and Nick Bosa both suffered season-ending injuries. George Kittle and Talanoa Hufanga also missed a significant portion of the season.
Even after overcoming those injuries and exceeding expectations, San Francisco’s projected win total has dropped entering 2026.
Last year, the Niners won those 12 games in the toughest division in football. The Seahawks won 14 games and beat the Rams, winners of 12 games, in the NFC title game. San Francisco fell at Seattle in the divisional round.
Odds: This upcoming season, San Francisco is the +305 third choice to win the NFC West, the +960 sixth choice to win the AFC and the +1900 11th choice to win the Super Bowl.

Get more from the National Football League Follow your favorites to get information about games, news and more

1 week ago
3

.jpg?mbid=social_retweet)




English (US)